26.07.2012

Опять результаты исследований эффектов экстази

Ну, в общем, читайте: экстази и память, некоторые новые данные.

Though ecstasy is known to cause health risks such as depression, sleep problems, severe anxiety and increasing other drug cravings, there has been a considerable amount of debate questioning whether or not government officials have over-reacted to ecstasy.

16.07.2012

Как достать всех в лабе

Гениальная статья о том, как стать "звездой" в лабе. Цитирую:


We all know them. You might even be one. The Lab Bastard is the one who considers himself (or herself!) superior to all other mere mortals in the lab. He would never degrade his talent by doing communal jobs in the lab, but swans around, absolutely sure that his experiments are most important and his results will be the most groundbreaking.
Above all, The Lab Bastard never misses an opportunity to claw his way to the top and doesn’t mind who he tramples on along the way.
I hope you don’t want to be The Lab Bastard. But in case you do, here are some useful tips:
When starting in a new lab, establish your superior credentials:
1) Never miss an opportunity to say how thing were done much better in your previous lab/your country.
2) Do a bit of namedropping; it always helps to impress the poor no-hopers you work with.
3) Declare equipment, supplies and methods that your colleagues use as outdated and insufficient for your needs. Order a lot of new stuff immediately, or even better, tell a technician do it for you.
Ensure that your talents are not wasted on menial tasks. Put technicians and your other colleagues in their rightful place as servants who are lucky to have a bit part to play in your journey to brilliance:
4) Make a point of never ordering ANYTHING. Ensure that no matter how small the order is, you pass it off to someone else to do it for you.
5) Never do any lab jobs – defrosting the freezer, cleaning the water bath, etc. It distracts you from doing experiments and there is always a backup freezer/another water bath, when they break because of the lack of maintenance.
6) If you finish a communal solution, be happy that there was enough left for you. You either won’t need it for a while, or, if it is widely used, somebody else will have to make it very soon.
7) Feel free to take stuff from other people’s benches. They have plenty of it or are not using it at the moment and you are working so much, you don’t have time to prepare or order this in advance.
Help No-one
8) Never volunteer to help anybody and never share your things, this will diminish your resources in exchange for a hazy possibility that people will pay you back in kind. They never do, you know, because you don’t.
Claim your rightful credit
9) Always ensure that you talk loudest in lab meetings – if you can talk over others, then so much the better. When you are making your razor sharp observations, be sure to keep eye contact with the boss at all times to ensure that your brilliance is noted.
10) A caveat to number 8: There is a time to volunteer to help people, and that is when they are close to publishing. At this point, use all of your skills and influence to secure the opportunity to do a (preferably very small) piece of work for the prospective author, then push like hell to be added as a co-author.
Спасибо http://bitesizebio.com/articles/how-to-be-the-lab-bastard/ 
Самое смешное - что такие везде находятся :) 

03.07.2012

Хроническая боль - в голове!

О хронической боли. Новости: 

When people have similar injuries, why do some end up with chronic pain while others recover and are pain free? The first longitudinal brain imaging study to track participants with a new back injury has found the chronic pain is all in their heads –- quite literally.
A new Northwestern Medicine study shows for the first time that chronic pain develops the more two sections of the brain --- related to emotional and motivational behavior --- talk to each other. The more they communicate, the greater the chance a patient will develop chronic pain.
The finding provides a new direction for developing therapies to treat intractable pain, which affects 30 to 40 million adults in the United States.
Researchers were able to predict, with 85 percent accuracy at the beginning of the study, which participants would go on to develop chronic pain based on the level of interaction between the frontal cortex and the nucleus accumbens.
The study is published in the journal Nature Neuroscience.
"For the first time we can explain why people who may have the exact same initial pain either go on to recover or develop chronic pain," said A. Vania Apakarian, senior author of the paper and professor of physiology at Northwestern University Feinberg School of Medicine.
"The injury by itself is not enough to explain the ongoing pain. It has to do with the injury combined with the state of the brain. This finding is the culmination of 10 years of our research."
The more emotionally the brain reacts to the initial injury, the more likely the pain will persist after the injury has healed. "It may be that these sections of the brain are more excited to begin with in certain individuals, or there may be genetic and environmental influences that predispose these brain regions to interact at an excitable level," Apkarian said.
The nucleus accumbens is an important center for teaching the rest of the brain how to evaluate and react to the outside world, Apkarian noted, and this brain region may use the pain signal to teach the rest of the brain to develop chronic pain.
"Now we hope to develop new therapies for treatment based on this finding," Apkarian added.
Chronic pain participants in the study also lost gray matter density, which is likely linked to fewer synaptic connections or neuronal and glial shrinkage, Apkarian said. Brain synapses are essential for communication between neurons.
"Chronic pain is one of the most expensive health care conditions in the U. S. yet there still is not a scientifically validated therapy for this condition," Apkarian said. Chronic pain costs an estimated $600 billion a year, according to a 2011 National Academy of Sciences report. Back pain is the most prevalent chronic pain condition.
A total of 40 participants who had an episode of back pain that lasted four to 16 weeks --- but with no prior history of back pain --- were studied. All subjects were diagnosed with back pain by a clinician. Brain scans were conducted on each participant at study entry and for three more visits during one year.
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Northwestern University: http://www.northwestern.edu